Phenazine

Phenazine

SCHEMBL8940300

CC(O)C(=O)O.c1ccc2nc3ccccc3nc2c1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1

The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
MAPT P10636 3/20 0.52
RXFP1 Q9HBX9 3/20 0.50
NPSR1 Q6W5P4 2/20 0.50
TP53 P04637 1/20 0.50
PRNP P04156 2/20 0.47
MEN1 O00255 2/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
KMT2A Q03164 2/20 0.47
KDM4E B2RXH2 2/20 0.47
MAPK10 P53779 1/20 0.47
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
HSD17B10 Q99714 1/20 0.44
APAF1 O14727 1/20 0.44
LMNA P02545 2/20 0.43
NQO2 P16083 1/20 0.43
PABPC1 P11940 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridine SCHEMBL10926258 0.88 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2MAPTRXFP1NPSR1
Phenazine SCHEMBL28705329 0.84 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2MAPTRXFP1NPSR1
Phenazine SCHEMBL27905609 0.84 MAPT (0.54) ALDH1A1SMN1; SMN2MAPTRXFP1NPSR1
Naphthalene SCHEMBL28289269 0.83 TP53 (0.58) ALDH1A1RXFP1NPSR1TP53PRNP
Quinoline SCHEMBL27820159 0.81 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2MAPTRXFP1NPSR1
Phenazine SCHEMBL6213173 0.80 MAPT (0.69) ALDH1A1SMN1; SMN2MAPTNPSR1TP53
Phenazine SCHEMBL28881744 0.79 SLC7A5 (0.58) ALDH1A1SMN1; SMN2MAPTRXFP1NPSR1
Anthracene SCHEMBL27602514 0.79 TP53 (0.52) ALDH1A1TP53MEN1KMT2AKDM4E
Biphenyl SCHEMBL27473317 0.78 PTGS2 (0.61) ALDH1A1SMN1; SMN2MAPTTP53ALOX15
Lactic Acid SCHEMBL8376573 0.77 TP53 (0.85) TP53ALOX15LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111818954-B Breath actuated inhaler 诺尔顿沃特福德有限公司 2021-11-05 CN disclosed
CN-111818954-A Breath actuated inhaler 诺尔顿沃特福德有限公司 2020-10-23 CN disclosed
EP-0710358-A4 POTENTIOMETRIC BIOSENSOR AND THE METHOD OF ITS USE BOEHRINGER MANNHEIM CORP (US) 1996-09-11 EP disclosed
EP-0710358-A1 POTENTIOMETRIC BIOSENSOR AND THE METHOD OF ITS USE BOEHRINGER MANNHEIM CORPORATION (US) 1996-05-08 EP disclosed
WO-1995003543-A1 POTENTIOMETRIC BIOSENSOR AND THE METHOD OF ITS USE BOEHRINGER MANNHEIM CORPORATION (US) 1995-02-02 WO disclosed
US-4391904-A Test strip kits in immunoassays and compositions therein SYVA COMPANY (US) 1983-07-05 US disclosed
US-4366241-A Concentrating zone method in heterogeneous immunoassays SYVA COMPANY (US) 1982-12-28 US disclosed
US-4299916-A COLORIMETRIC ANALYSIS OF ANALYTES SYVA COMPANY (US) 1981-11-10 US disclosed