Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10927373 | 0.90 | RAB9A (0.50) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10924714 | 0.86 | HDAC6 (0.44) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10928518 | 0.86 | RAB9A (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL10927840 | 0.78 | MAPT (0.44) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4029179 | 0.76 | PPARA (0.52) | RAB9ANPC1ALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL10925827 | 0.75 | SMN1; SMN2 (0.43) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10924399 | 0.75 | THRB (0.46) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10926206 | 0.75 | ALDH1A1 (0.43) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4033544 | 0.75 | PPARA (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL10924712 | 0.75 | RAB9A (0.55) | RAB9ANPC1ALDH1A1SMN1; SMN2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | claimed |
| EP-0189771-A3 | (ISOXAZOL-3-YL)ARYLMETHANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0189771-A2 | (Isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-08-06 | — | — | EP | disclosed |
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |