Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10928708 | 0.83 | ACE (0.49) | LMNA | |
| SCHEMBL10932475 | 0.81 | CETP (0.35) | FOLH1LMNASMN1; SMN2 | |
| SCHEMBL9417120 | 0.78 | HTT (0.47) | HTTTGM2SLC1A3SLC1A1LMNA | |
| SCHEMBL13853971 | 0.78 | HTT (0.58) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL13725441 | 0.76 | HTT (0.59) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL10928732 | 0.76 | PPARG (0.36) | SMN1; SMN2MMP2MAPT | |
| SCHEMBL7377154 | 0.75 | PPARG (0.43) | MMP3MMP9 | |
| SCHEMBL7377157 | 0.75 | PPARG (0.43) | MMP3MMP9 | |
| SCHEMBL9123690 | 0.75 | FOLH1 (0.51) | HTTTGM2MMP3FOLH1MMP2 | |
| SCHEMBL9123699 | 0.75 | FOLH1 (0.51) | HTTTGM2MMP3FOLH1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560680-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-12-24 | — | — | US | disclosed |
| US-4452791-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-05 | — | — | US | disclosed |