SCHEMBL10929433

SCHEMBL10929433

COc1ccc(/C=C\C(=O)OC(=O)OC(=O)/C=C\c2ccc(OC)c(OC)c2)cc1OC

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.69
ALDH1A1 P00352 5/20 0.69
SMN1; SMN2 Q16637 4/20 0.69
HPGD P15428 1/20 0.69
ALOX15 P16050 1/20 0.69
MAPK1 P28482 1/20 0.69
HSD17B10 Q99714 1/20 0.69
NFE2L2 Q16236 1/20 0.67
KMT2A Q03164 5/20 0.65
ABCG2 Q9UNQ0 2/20 0.65
MEN1 O00255 1/20 0.65
FDPS P14324 2/20 0.62
EPHX2 P34913 1/20 0.59
TNFRSF1A P19438 1/20 0.58
MAPT P10636 2/20 0.58
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
TTR P02766 1/20 0.58
JAK2 O60674 1/20 0.57
GAA P10253 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10929424 0.89 SMN1; SMN2 (0.71) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL10929437 0.89 SMN1; SMN2 (0.71) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL9972286 0.89 FDPS (0.68) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411955 0.87 FDPS (0.80) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411956 0.87 FDPS (0.80) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL12538642 0.84 SMN1; SMN2 (0.69) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL30493821 0.83 NFKB1 (0.79) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL2743876 0.83 NFKB1 (0.79) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL2743877 0.83 NFKB1 (0.79) KDM4EALDH1A1SMN1; SMN2HPGDALOX15
SCHEMBL562443 0.81 KDM4E (0.75) KDM4EALDH1A1SMN1; SMN2HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60032756-A None JP disclosed
JP-S6032756-A PRODUCTION OF N-(CIS-3,4-DIMETHOXYCINNAMOYL)-ANTHRANYLIC ACID NIPPON REDARII KK 1985-02-19 JP disclosed