Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.79 |
| ▸ | JUN | P05412 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.75 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.75 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.75 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.75 |
| ▸ | STAT3 | P40763 | 1/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.75 |
| ▸ | RELA | Q04206 | 1/20 | 0.75 |
| ▸ | CA2 | P00918 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743876 | 1.00 | NFKB1 (0.79) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL30493821 | 1.00 | NFKB1 (0.79) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL2744668 | 0.92 | NFKB1 (0.74) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL14982038 | 0.92 | NFKB1 (0.68) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL2744234 | 0.92 | CYP2D6 (0.91) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL2744131 | 0.92 | NFKB1 (0.68) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL2744233 | 0.92 | CYP2D6 (0.91) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL2744663 | 0.92 | NFKB1 (0.74) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL13039663 | 0.92 | KDM4E (0.82) | NFKB1JUNKDM4EALDH1A1HPGD | |
| SCHEMBL28356985 | 0.92 | CYP2D6 (0.69) | NFKB1JUNKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432401-B2 | Method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | Fundação de Amparo a Pesquisa Do Estado de São Paulo (BR) | 2008-10-07 | — | — | US | claimed |
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC UNM (US) | 2016-02-11 | — | — | US | disclosed |
| US-9187397-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC.UNM | 2015-01-08 | — | — | US | disclosed |
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
| EP-1572614-B1 | METHOD FOR THE PREPARATION OF 1,5-BIS(4-HYDROXY-3-METOXY-PHENYL)-PENTA-1,4-DIEN-3-ONE | FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO (BR) | 2013-12-25 | — | — | EP | disclosed |
| US-20130158024-A1 | TRICYCLIC NECROSTATIN COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-06-20 | — | — | US | disclosed |
| US-8324262-B2 | Tricyclic necrostatin compounds | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324262-B2 | Tricyclic necrostatin compounds | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8178727-B2 | Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer | NATIONAL UNIVERSITY CORPORATION TOHOKU UNIVERSITY (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20100190836-A1 | Compounds, Screens, and Methods of Treatment | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-29 | — | — | US | disclosed |
| US-20100190836-A1 | Compounds, Screens, and Methods of Treatment | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-29 | — | — | US | disclosed |
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | SHIBATA, HIROYUKI (JP) | 2010-06-17 | — | — | US | disclosed |
| US-7432401-B2 | Method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | Fundação de Amparo a Pesquisa Do Estado de São Paulo (BR) | 2008-10-07 | — | — | US | disclosed |
| US-20070060644-A1 | Therapeutic curcumin derivatives | STC.UNM | 2007-03-15 | — | — | US | disclosed |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | STC.UNM | 2006-12-07 | — | — | US | disclosed |
| US-20060128997-A1 | New method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO (BR) | 2006-06-15 | — | — | US | disclosed |
| EP-1572614-A2 | NEW METHOD FOR THE PREPARATION OF 1,5-BIS(4-HYDROXY-3-METOXY-PHENYL)-PENTA-1,4-DIEN-3-ONE AND DERIVATIVES WITH ANTITUMORAL PROPERTIES | Fundacio de Amparo Pesquisa do Estado des Sao Paulo (BR) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004047716-A2 | NEW METHOD FOR THE PREPARATION OF 1,5-BIS(4-HYDROXY-3-METOXY-PHENYL)-PENTA-1,4-DIEN-3-ONE AND DERIVATIVES WITH ANTITUMORAL PROPERTIES | Fundação De Amparo À Pesquisa Do Estado de São Paulo (BR) | 2004-06-10 | — | — | WO | disclosed |
| US-RE29358-E | ANTI-MALARIA AND ANTI-TUBERCULOSIS AGENTS | AMERICAN CYANAMID COMPANY (US) | 1977-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | MYC, CCNE2, CCNE1 | NFKB1 328/4885JUN 60/4885KDM4E 623/4885 |
| US-20100190836-A1 | Compounds, Screens, and Methods of Treatment | NLN, HTRA2, CLN6 | NFKB1 1024/4885JUN 2363/4885KDM4E 4533/4885 |
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885KDM4E 3658/4885 |
| US-20070060644-A1 | Therapeutic curcumin derivatives | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885KDM4E 3658/4885 |
| US-20060128997-A1 | New method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | DDB1, ANXA1, ANXA5 | NFKB1 310/4885JUN 3433/4885KDM4E 2890/4885 |
| US-20130158024-A1 | TRICYCLIC NECROSTATIN COMPOUNDS | HTRA2, AIFM1, BAD | NFKB1 1051/4885JUN 940/4885KDM4E 4694/4885 |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885KDM4E 3658/4885 |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | BRCA1, VHL, TP53 | NFKB1 73/4885JUN 786/4885KDM4E 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.