Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10930026 | 0.87 | TAAR1 (0.52) | TAAR1CYP1A2CYP2D6TSHRLMNA | |
| Hydrochloric Acid SCHEMBL10931958 | 0.86 | TAAR1 (0.51) | TAAR1CYP1A2CYP2D6TSHRLMNA | |
| SCHEMBL6516873 | 0.81 | MAOA (0.41) | CYP2D6 | |
| SCHEMBL10929819 | 0.80 | TAAR1 (0.43) | TAAR1CYP1A2CYP2D6TSHRLMNA | |
| SCHEMBL27518334 | 0.72 | HSD11B1 (0.45) | ADRA2AADRA1A | |
| SCHEMBL10930867 | 0.70 | CYP19A1 (0.58) | TAAR1LMNAADRA2AADRA2BADRA2C | |
| SCHEMBL953620 | 0.69 | TAAR1 (0.68) | TAAR1CYP1A2CYP2D6TSHRLMNA | |
| SCHEMBL12157841 | 0.69 | TAAR1 (0.50) | TAAR1CYP1A2CYP2D6TSHRLMNA | |
| SCHEMBL1254617 | 0.68 | HRH1 (0.41) | CYP1A2CYP2D6TSHRLMNAADRA2A | |
| SCHEMBL20922751 | 0.68 | HRH1 (0.51) | CYP1A2CYP2D6TSHRADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4540705-A | Antidepressant imidazolines and related compounds | STERLING DRUG INC. (US) | 1985-09-10 | — | — | US | claimed |
| US-4540705-A | Antidepressant imidazolines and related compounds | STERLING DRUG INC. (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0125410-A2 | Imidazolines and related compounds and preparation thereof | STERLING DRUG INC. (US) | 1984-11-21 | — | — | EP | disclosed |