Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451691 | 0.85 | MAPT (0.37) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL578916 | 0.83 | CYP4F2 (0.36) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL1072447 | 0.83 | CYP4F2 (0.36) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL3133963 | 0.83 | CYP4F2 (0.36) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL18759662 | 0.82 | CYP4F2 (0.40) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL16048 | 0.82 | CYP4F2 (0.40) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL543816 | 0.81 | CYP4F2 (0.35) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL19278938 | 0.80 | CYP4F2 (0.39) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL413276 | 0.80 | CYP4F2 (0.39) | CYP4F2CYP4A11MMP8ALDH1A1PKM | |
| SCHEMBL7828510 | 0.80 | CYP4F2 (0.32) | CYP4F2CYP4A11MMP8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4540705-A | Antidepressant imidazolines and related compounds | STERLING DRUG INC. (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0125410-A2 | Imidazolines and related compounds and preparation thereof | STERLING DRUG INC. (US) | 1984-11-21 | — | — | EP | disclosed |
| US-4234487-A | Process of making a carbazole acetic acid | HOFFMANN-LA ROCHE INC. (US) | 1980-11-18 | — | — | US | disclosed |
| EP-0006208-A1 | Process for the preparation of carbazoles and an intermediate therefor | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-01-09 | — | — | EP | disclosed |
| US-4179443-A | ANTIINFLAMMATORY AGENTS, ANTIRHEUMATIC AGENTS, CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1979-12-18 | — | — | US | disclosed |
| US-4146542-A | ANTIINFLAMMATORY AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-03-27 | — | — | US | disclosed |