Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10930331 | 0.83 | CYP4F2 (0.37) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL5451691 | 0.83 | MAPT (0.37) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL3133963 | 0.81 | CYP4F2 (0.36) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL1072447 | 0.81 | CYP4F2 (0.36) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL16048 | 0.80 | CYP4F2 (0.40) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL18759662 | 0.80 | CYP4F2 (0.40) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL543816 | 0.80 | CYP4F2 (0.35) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL413276 | 0.79 | CYP4F2 (0.39) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL19278938 | 0.79 | CYP4F2 (0.39) | CYP4F2CYP4A11MMP8PKMALDH1A1 | |
| SCHEMBL8045727 | 0.77 | MMP8 (0.35) | CYP4F2CYP4A11MMP8PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| US-9861652-B2 | 2′ Fluoronucleosides | EMORY UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | EMORY UNIVERSITY | 2016-06-09 | — | — | US | disclosed |
| EP-1861401-B1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-18 | — | — | EP | disclosed |
| US-9180138-B2 | 2′-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2417141-B1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2013-10-16 | — | — | EP | disclosed |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | SCHINAZI RAYMOND F (US) | 2013-06-20 | — | — | US | disclosed |
| US-8415375-B2 | 2-hydroxyethyl-1H-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-04-09 | — | — | US | disclosed |
| EP-0449884-A4 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0449884-A1 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | ABBOTT LABORATORIES (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990006937-A1 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |
| US-4375563-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1983-03-01 | — | — | US | disclosed |
| US-4338253-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4321209-A | Fluorinated aromatic polyenes | HOFFMANN-LA ROCHE INC. (US) | 1982-03-23 | — | — | US | disclosed |
| US-4266073-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-05-05 | — | — | US | disclosed |
| US-4201727-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-06 | — | — | US | disclosed |
| US-4169100-A | FLUORO AND TRIFLUOROMETHYL SUBSTITUTED 9-(4-ALKOXY-2,3,6-TRIALKYLPHENYL)-2,4,6,8-NONATETRAENOIC ACIDS, ESTERS AND AMIDES, ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-09-25 | — | — | US | disclosed |
| US-4137246-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | CYP4F2 444/4885CYP4A11 329/4885MMP8 301/4885 |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | PNP, BCL3, NPC1 | CYP4F2 758/4885CYP4A11 750/4885MMP8 3390/4885 |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | PNP, BCL3, FUBP3 | CYP4F2 760/4885CYP4A11 707/4885MMP8 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.