Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937760 | 0.83 | KIT (0.45) | GRM1ALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL13715917 | 0.82 | CA1 (0.55) | GAAALDH1A1SMN1; SMN2ALOX15KDM4E | |
| SCHEMBL10593982 | 0.81 | TDP1 (0.33) | GAAALDH1A1GRM4HTTNPC1 | |
| SCHEMBL10933029 | 0.80 | BRD4 (0.46) | GAAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12892210 | 0.79 | JAK2 (0.55) | ALDH1A1GRM4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10934234 | 0.79 | HDAC6 (0.50) | GRM4HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13715920 | 0.79 | KDM4E (0.53) | GAAALDH1A1CYP1A2ALOX15KDM4E | |
| SCHEMBL10935199 | 0.78 | CA1 (0.49) | GRM4HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10935204 | 0.78 | CA1 (0.49) | GRM4HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11560867 | 0.76 | KLKB1 (0.50) | GRM4SMN1; SMN2CYP1A2ALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0053789-B1 | 2-PYRIDINECARBOXAMIDE DERIVATIVE, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION, USEFUL AS AN ANTI-ALLERGIC AGENT | Tanabe Seiyaku Co., Ltd. (JP) | 1985-03-27 | — | — | EP | disclosed |
| US-4404214-A | 2-Pyridinecarboxamide derivatives compositions containing same and method of using same | TANABE SEIYAKU CO., LTD. (JP) | 1983-09-13 | — | — | US | disclosed |
| EP-0053789-A1 | 2-Pyridinecarboxamide derivative, process for preparing same and pharmaceutical composition, useful as an anti-allergic agent | Tanabe Seiyaku Co., Ltd. (JP) | 1982-06-16 | — | — | EP | disclosed |