Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.44 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936211 | 0.88 | RIPK1 (0.55) | RIPK1MCL1MMP8ALDH1A1MAPT | |
| SCHEMBL10938223 | 0.85 | RIPK1 (0.52) | RIPK1MCL1MMP8OPRK1SMN1; SMN2 | |
| SCHEMBL1709321 | 0.77 | RIPK1 (1.00) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL1709337 | 0.77 | RIPK1 (0.75) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL25464672 | 0.76 | RIPK1 (0.68) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL10990271 | 0.76 | RIPK1 (0.68) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL557055 | 0.76 | RIPK1 (0.68) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL7438658 | 0.76 | RIPK1 (0.68) | RIPK1MMP8ALDH1A1MAPTOPRK1 | |
| SCHEMBL1516186 | 0.74 | RIPK1 (0.71) | RIPK1MMP8ALDH1A1OPRK1SMN1; SMN2 | |
| SCHEMBL25932261 | 0.74 | MCL1 (0.43) | MCL1MMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4537781-A | Pharmaceutically useful malonamides | RESEARCH CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0135189-A2 | Pharmaceutically useful malonamides | Research Corporation (US) | 1985-03-27 | — | — | EP | disclosed |