Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936348 | 0.85 | GAA (0.46) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3174611 | 0.83 | TUBB1 (0.44) | RXRAMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL3170879 | 0.80 | MEN1 (0.42) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| 3,5-Dimethoxybenzoic Acid SCHEMBL503889 | 0.78 | RXRA (0.64) | RXRACA1CA2ABCG2KDM4E | |
| SCHEMBL21686698 | 0.77 | KDM4E (0.56) | RXRACYP1A2CYP3A4CYP2C9CA1 | |
| 3,5-Dimethoxybenzoic Acid SCHEMBL20592058 | 0.76 | RXRA (0.62) | RXRACA1CA2ABCG2KDM4E | |
| 3,5-Dimethoxybenzoic Acid SCHEMBL5668197 | 0.76 | RXRA (0.62) | RXRACA1CA2ABCG2KDM4E | |
| SCHEMBL10939230 | 0.75 | TUBB1 (0.47) | RXRATUBB1CA1CA2KDM4E | |
| SCHEMBL1817008 | 0.75 | ALDH1A1 (0.58) | RXRAMEN1KMT2ATUBB1ABCG2 | |
| 3,5-Dimethoxybenzoic Acid SCHEMBL9426765 | 0.74 | RXRA (0.60) | RXRACA1CA2ABCG2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |