Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696988 | 0.77 | MAPT (0.37) | MAPTHPGDALDH1A1L3MBTL1POLB | |
| SCHEMBL29754890 | 0.74 | CA1 (0.33) | HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL596873 | 0.74 | MCL1 (0.36) | MAPTHPGDALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL17964147 | 0.74 | CA1 (0.33) | HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10941412 | 0.73 | ALDH1A1 (0.35) | MAPTALDH1A1L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL1632856 | 0.72 | MAPT (0.35) | MAPTHPGDALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL19778352 | 0.71 | ALDH1A1 (0.34) | MAPTHPGDALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL1633719 | 0.71 | ALDH1A1 (0.41) | MAPTHPGDALDH1A1L3MBTL1POLB | |
| SCHEMBL28573075 | 0.71 | LMNA (0.41) | MAPTHPGDALDH1A1L3MBTL1POLB | |
| SCHEMBL27719945 | 0.70 | SMN1; SMN2 (0.34) | MAPTHPGDALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |