SCHEMBL10936909

SCHEMBL10936909

Cc1c[c]ccc1-c1cc(Cl)cc(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.32
CNR1 P21554 2/20 0.32
CNR2 P34972 2/20 0.32
CD274 Q9NZQ7 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TSHR P16473 1/20 0.31
AKR1C3 P42330 1/20 0.30
AKR1C2 P52895 1/20 0.30
APP P05067 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7873514 0.84 ESR2 (0.45) ESR2
SCHEMBL10939037 0.82 AHR (0.35) SMN1; SMN2TSHR
SCHEMBL9009463 0.78 AHR (0.47) RAPGEF4AKR1C3AKR1C2APP
SCHEMBL694819 0.78 PTGS2 (0.43) RAPGEF4AKR1C3AKR1C2
SCHEMBL9649086 0.77 TSHR (0.31) TSHR
SCHEMBL2012935 0.77 RAPGEF4 (0.32) RAPGEF4
SCHEMBL14480559 0.76
SCHEMBL2431965 0.74 AKR1C3 (0.43) RAPGEF4AKR1C3AKR1C2
SCHEMBL5517642 0.74 CNR1 (0.34) CNR1CNR2
SCHEMBL3544339 0.74 ACHE (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4524168-A AZO DYES CIBA-GEIGY CORPORATION (US) 1985-06-18 US disclosed