Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936378 | 0.81 | TDP1 (0.58) | CYP2C9MAPTGAAALDH1A1KMT2A | |
| SCHEMBL4529606 | 0.80 | CYP1A2 (0.79) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10946156 | 0.79 | NPC1 (0.61) | MAPTGAAALDH1A1KMT2ALMNA | |
| SCHEMBL10940646 | 0.79 | ALDH1A1 (0.55) | MAPTGAAALDH1A1KMT2ALMNA | |
| Veratric Acid Methyl Ester SCHEMBL2050732 | 0.79 | MAPT (0.86) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Veratric Acid Methyl Ester SCHEMBL29573244 | 0.79 | MAPT (0.86) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10936334 | 0.79 | ALDH1A1 (0.57) | TSHRCYP1A2CYP3A4CYP2C9MAPT | |
| SCHEMBL10940684 | 0.78 | ALDH1A1 (0.49) | TSHRGAAALDH1A1KMT2ALMNA | |
| SCHEMBL10941178 | 0.77 | EGFR (0.52) | TSHRMAPTGAAALDH1A1LMNA | |
| SCHEMBL10941698 | 0.77 | GPR17 (0.47) | TSHRGAAALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |