Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.49 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10939230 | 0.86 | TUBB1 (0.47) | BAZ2BBAZ2ATUBB1POLBCA1 | |
| SCHEMBL70354 | 0.79 | BAZ2B (0.71) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL10936334 | 0.79 | ALDH1A1 (0.57) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL10936378 | 0.78 | TDP1 (0.58) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL10939136 | 0.78 | TSHR (0.58) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| Methyl 3,5-Dimethoxybenzoate SCHEMBL204865 | 0.77 | CA1 (0.61) | ALDH1A1GAALMNAPOLBCA1 | |
| SCHEMBL10946156 | 0.77 | NPC1 (0.61) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL10940646 | 0.77 | ALDH1A1 (0.55) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL409737 | 0.76 | BAZ2B (0.57) | ALDH1A1BAZ2BBAZ2AGAALMNA | |
| SCHEMBL10936348 | 0.76 | GAA (0.46) | ALDH1A1GAATUBB1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |