Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | AR | P10275 | 4/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.60 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.58 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL6 | P05231 | 1/20 | 0.58 |
| ▸ | GLUL | P15104 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940470 | 1.00 | PGR (0.72) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL10940339 | 0.93 | PGR (0.69) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL10940343 | 0.93 | PGR (0.69) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL5602237 | 0.93 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL5602245 | 0.93 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL9487612 | 0.93 | PGR (0.78) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL2299113 | 0.93 | PGR (0.78) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL11016450 | 0.91 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL11016446 | 0.91 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL11429938 | 0.91 | PGR (0.75) | PGRHIF1ANR3C1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072546-B1 | HYDROCORTISONE DERIVATIVES, THEIR PREPARATION AND THEIR UTILIZATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-09 | — | — | EP | claimed |
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | claimed |
| EP-0072546-A1 | Hydrocortisone derivatives, their preparation and their utilization | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-02-23 | — | — | EP | claimed |
| EP-0072546-B1 | HYDROCORTISONE DERIVATIVES, THEIR PREPARATION AND THEIR UTILIZATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-09 | — | — | EP | disclosed |
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | disclosed |
| EP-0072546-A1 | Hydrocortisone derivatives, their preparation and their utilization | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-02-23 | — | — | EP | disclosed |