Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.64 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.64 |
| ▸ | AR | P10275 | 4/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | IL6 | P05231 | 1/20 | 0.63 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.63 |
| ▸ | GLUL | P15104 | 1/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299113 | 1.00 | PGR (0.78) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL5602237 | 0.93 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL5602245 | 0.93 | PGR (0.80) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL11429938 | 0.93 | PGR (0.75) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL10940461 | 0.93 | PGR (0.72) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL10940470 | 0.93 | PGR (0.72) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL2252725 | 0.92 | NR3C1 (0.75) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL18971498 | 0.92 | PGR (0.66) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL6859003 | 0.91 | NR3C1 (0.73) | PGRHIF1ANR3C1LMNACYP3A4 | |
| SCHEMBL6859007 | 0.91 | NR3C1 (0.73) | PGRHIF1ANR3C1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0256095-A4 | ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES. | UNIV FLORIDA AGRICULT MECH (US) | 1988-09-28 | — | — | EP | claimed |
| US-4762919-A | STEROIDS | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1988-08-09 | — | — | US | claimed |
| EP-0256095-A1 | ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES. | UNIV FLORIDA AGRICULT MECH (US) | 1988-02-24 | — | — | EP | claimed |
| WO-1987005028-A1 | ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1987-08-27 | — | — | WO | claimed |
| EP-0256095-B1 | ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5200518-A | Reduced side effcts | KANGWEON NATIONAL UNIVERSITY (KR) | 1993-04-06 | — | — | US | disclosed |
| US-4762919-A | STEROIDS | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1988-08-09 | — | — | US | disclosed |
| US-4290963-A | HEATING ONE OF THE PREGNANE SERIES | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-09-22 | — | — | US | disclosed |
| US-4036831-A | Trimethyl siloxane steroid intermediates | STEROID DEVELOPMENT COMPANY ESTABLISHMENT (CH) | 1977-07-19 | — | — | US | disclosed |