Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 6/20 | 0.34 |
| ▸ | CA1 | P00915 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940664 | 0.81 | ACE (0.75) | ACEFFAR2LMNAHTT | |
| SCHEMBL10941007 | 0.79 | ACE (0.77) | ACEFFAR2LMNAHTT | |
| SCHEMBL10942769 | 0.77 | ACE (0.54) | ACEFFAR2LMNAHTT | |
| SCHEMBL11004289 | 0.77 | ACE (0.80) | ACEFFAR2LMNAHTT | |
| SCHEMBL10944184 | 0.74 | ACE (0.80) | ACEFFAR2LMNAHTT | |
| SCHEMBL10944736 | 0.74 | ACE (0.58) | ACEFFAR2LMNAHTT | |
| SCHEMBL10946334 | 0.73 | ACE (0.49) | ACEFFAR2 | |
| SCHEMBL8398559 | 0.72 | ACE (0.80) | ACEFFAR2LMNAHTT | |
| SCHEMBL10942716 | 0.72 | ACE (0.53) | ACEFFAR2LMNAHTT | |
| SCHEMBL683207 | 0.72 | ACE (0.87) | ACEFFAR2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |