Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 9/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940664 | 0.84 | ACE (0.75) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL10945275 | 0.83 | FFAR2 (0.48) | ACELMNAFFAR2ALDH1A1TSHR | |
| SCHEMBL10941007 | 0.81 | ACE (0.77) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL11004289 | 0.81 | ACE (0.80) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL10940708 | 0.77 | ACE (0.53) | ACELMNAFFAR2HTT | |
| SCHEMBL10944184 | 0.76 | ACE (0.80) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL11104668 | 0.76 | ACE (0.48) | ACELMNAFFAR2 | |
| SCHEMBL10944736 | 0.75 | ACE (0.58) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL11219793 | 0.75 | ACE (0.43) | ACELMNAFFAR2HTT | |
| SCHEMBL10940821 | 0.74 | GAA (0.46) | ACELMNAFFAR2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |