Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11059109 | 0.87 | ACE (0.65) | ACEHSD17B10KIF11FFAR2GAA | |
| SCHEMBL10943470 | 0.82 | ACE (0.43) | ACEHSD17B10FFAR2GAAPOLB | |
| SCHEMBL10942483 | 0.82 | ACE (0.43) | ACEHSD17B10FFAR2GAAPOLB | |
| SCHEMBL10942993 | 0.81 | L3MBTL1 (0.44) | ACEPOLB | |
| SCHEMBL10944246 | 0.81 | L3MBTL1 (0.44) | ACEPOLB | |
| SCHEMBL10939993 | 0.80 | ACE (0.57) | ACEHSD17B10FFAR2GAAPOLB | |
| SCHEMBL10945382 | 0.80 | ACE (0.41) | ACEHSD17B10FFAR2GAAPOLB | |
| SCHEMBL10941190 | 0.80 | ACE (0.41) | ACEHSD17B10FFAR2GAAPOLB | |
| SCHEMBL11385315 | 0.80 | ACE (0.43) | ACEHSD17B10KIF11FFAR2GAA | |
| SCHEMBL10945754 | 0.80 | TBXAS1 (0.47) | ACEHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |