Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 9/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938815 | 0.90 | ACE (0.71) | ACEKMT2ALMNAFFAR2HTT | |
| SCHEMBL11066115 | 0.90 | ACE (0.71) | ACEKMT2ALMNAFFAR2HTT | |
| SCHEMBL10966510 | 0.85 | ACE (0.49) | ACEKMT2ALMNA | |
| SCHEMBL10971131 | 0.84 | ACE (0.48) | ACEKMT2ALMNAHTTALDH1A1 | |
| SCHEMBL10938561 | 0.83 | ACE (0.77) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL10966516 | 0.80 | ACE (0.50) | ACEKMT2ALMNAFFAR2HTT | |
| SCHEMBL10968013 | 0.80 | ACE (0.54) | ACEKMT2ALMNAFFAR2ALDH1A1 | |
| SCHEMBL10968295 | 0.79 | ACE (0.71) | ACEKMT2ALMNAFFAR2HTT | |
| SCHEMBL10979196 | 0.79 | ACE (0.77) | ACEKMT2ALMNAFFAR2HTT | |
| SCHEMBL11185062 | 0.79 | ACE (0.77) | ACEKMT2ALMNAFFAR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067885-B1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | claimed |
| US-4464371-A | HYPOTENSIVE AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | claimed |
| EP-0067885-A1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-12-29 | — | — | EP | claimed |
| EP-0067885-B1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |
| US-4464371-A | HYPOTENSIVE AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| EP-0067885-A1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-12-29 | — | — | EP | disclosed |