Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 12/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104668 | 0.89 | ACE (0.48) | ACELMNAFFAR2 | |
| SCHEMBL11104265 | 0.89 | ACE (0.46) | ACELMNAFFAR2HTT | |
| SCHEMBL11194036 | 0.85 | ACE (0.59) | ACELMNAFFAR2HTT | |
| SCHEMBL11196868 | 0.81 | HTT (0.32) | ACELMNAFFAR2HTT | |
| SCHEMBL11201160 | 0.78 | GAA (0.47) | FFAR2 | |
| SCHEMBL11104269 | 0.78 | LMNA (0.46) | ACELMNAFFAR2HTT | |
| SCHEMBL11219804 | 0.78 | ACE (0.36) | ACELMNAFFAR2HTT | |
| SCHEMBL11262988 | 0.76 | POLB (0.48) | ACEFFAR2 | |
| SCHEMBL11062257 | 0.76 | ACE (0.55) | ACELMNAFFAR2HTT | |
| SCHEMBL11184570 | 0.75 | POLB (0.47) | FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |