Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KRAS | P01116 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10819611 | 0.79 | MAPT (0.61) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL4074043 | 0.78 | MAPT (0.56) | HTTMAPTALDH1A1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL11861707 | 0.77 | HTR6 (0.51) | HTTMAPTALDH1A1GAACYP3A4 | |
| SCHEMBL9271449 | 0.76 | MAPT (0.57) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL10946479 | 0.72 | PKM (0.51) | HTTMAPTALDH1A1KDM4ECYP3A4 | |
| SCHEMBL18383120 | 0.71 | MAPT (0.69) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL14979225 | 0.71 | MEN1 (0.52) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL669111 | 0.70 | HTT (0.73) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL27228470 | 0.69 | GRIN2D (0.54) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL10943500 | 0.69 | LOXL2 (0.47) | MAPTALDH1A1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4495352-A | HYPOTENSIVE AGENTS; VASODILATION; ADRENERGIC BLOCKING ACTION | MEAD JOHNSON & COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| US-4314943-A | ANTIHYPERTENSIVE AGENTS; VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1982-02-09 | — | — | US | disclosed |
| US-4234595-A | HYPOTENSIVE AGENTS; ADRENERGIC BLOCKING AGENTS; VASODILATION | MEAD JOHNSON & COMPANY (US) | 1980-11-18 | — | — | US | disclosed |