Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093649 | 0.78 | PTGDR2 (0.38) | PTGDR2PIK3CDPIK3CAHSP90AA1HSP90AB1 | |
| SCHEMBL1094851 | 0.77 | — | — | |
| SCHEMBL17270527 | 0.74 | SCN9A (0.44) | SCN9A | |
| SCHEMBL327000 | 0.74 | PTPN22 (0.35) | — | |
| SCHEMBL16177624 | 0.74 | — | — | |
| SCHEMBL1095194 | 0.72 | SCN9A (0.57) | SCN9ASCN5A | |
| SCHEMBL1094339 | 0.71 | SCN8A (0.43) | PTGDR2HSP90AA1HSP90AB1AKR1C3SCN9A | |
| SCHEMBL17270522 | 0.69 | ATAD2 (0.35) | PTGDR2PIK3CALMNA | |
| SCHEMBL1094338 | 0.64 | PIK3CD (0.38) | PTGDR2PIK3CDPIK3CAHSP90AA1HSP90AB1 | |
| SCHEMBL17270558 | 0.63 | TAS2R14 (0.39) | PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |