Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.45 |
| ▸ | AR | P10275 | 7/20 | 0.43 |
| ▸ | PGR | P06401 | 8/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945250 | 0.90 | PGR (0.52) | NR3C1ARPGRCYP3A4NR3C2 | |
| SCHEMBL10945949 | 0.86 | NR3C1 (0.54) | NR3C1ARPGRCYP3A4CYP2C19 | |
| SCHEMBL8408966 | 0.81 | NR3C1 (0.58) | NR3C1ARPGRCYP3A4CYP2C8 | |
| SCHEMBL8407025 | 0.81 | NR3C1 (0.58) | NR3C1ARPGRCYP3A4CYP2C8 | |
| SCHEMBL10947612 | 0.77 | PGR (0.41) | NR3C1ARPGRCYP3A4NR3C2 | |
| SCHEMBL5150213 | 0.77 | PGR (0.54) | NR3C1ARPGRCYP3A4NR3C2 | |
| SCHEMBL10944309 | 0.76 | NR3C1 (0.66) | NR3C1ARPGRCYP3A4CYP2C19 | |
| SCHEMBL10943281 | 0.75 | CYP19A1 (0.46) | ARPGRNR3C2 | |
| SCHEMBL10596154 | 0.75 | PGR (0.54) | NR3C1ARPGRCYP3A4NR3C2 | |
| SCHEMBL7949842 | 0.74 | PGR (0.52) | NR3C1ARPGRCYP3A4NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4557867-A | CONTRACEPTIVES | THE UPJOHN COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4557867-A | CONTRACEPTIVES | THE UPJOHN COMPANY (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0145493-A2 | 11-Difluoromethyl and 11-fluoromethylene steroids | THE UPJOHN COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |