Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109396 | 0.84 | NOS2 (0.48) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| Nitric Acid SCHEMBL21957805 | 0.84 | POLB (0.43) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| SCHEMBL6036699 | 0.74 | ALDH1A1 (0.47) | TSHRCYP3A4ALDH1A1TDP1POLB | |
| Hydroxyamine SCHEMBL28193821 | 0.73 | NOS3 (0.38) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| SCHEMBL5667505 | 0.73 | NOS2 (0.48) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| Nitric Acid SCHEMBL21957719 | 0.73 | TSHR (0.50) | TSHRCYP3A4ALDH1A1TDP1POLB | |
| SCHEMBL30117633 | 0.73 | NOS3 (0.41) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| SCHEMBL215981 | 0.73 | NOS3 (0.41) | TSHRCYP3A4ALDH1A1TDP1NOS3 | |
| SCHEMBL77335 | 0.72 | POLB (0.46) | TSHRCYP3A4ALDH1A1TDP1POLB | |
| SCHEMBL9497778 | 0.71 | NOS2 (0.44) | TSHRCYP3A4ALDH1A1TDP1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4510181-A | FORMING CORROSION PROTECTIVE LAYER ON SURFACE USING VINYL MONOMERS AND/OR VINLY GROUP CONTAINING OLIGOMER | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1985-04-09 | — | — | US | disclosed |