Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 10/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 10/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 10/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 10/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10944369 | 0.91 | SMN1; SMN2 (0.45) | ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL10944246 | 0.88 | L3MBTL1 (0.44) | ALDH1A1KMT2APOLB | |
| SCHEMBL10944629 | 0.83 | ALDH1A1 (0.42) | ALDH1A1HIF1AMEN1LMNACYP1A2 | |
| SCHEMBL10942943 | 0.79 | L3MBTL1 (0.43) | ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL10945919 | 0.79 | SMN1; SMN2 (0.43) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL10944724 | 0.77 | SMN1; SMN2 (0.42) | ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL10945129 | 0.76 | L3MBTL1 (0.43) | ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL10942643 | 0.76 | POLB (0.43) | ALDH1A1MEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10941190 | 0.72 | ACE (0.41) | ALDH1A1POLB | |
| SCHEMBL10944276 | 0.72 | ACE (0.45) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | claimed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | claimed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | claimed |