Leucine

Leucine

SCHEMBL10948372

CC(C)C[C@H](N)C(=O)O.[2H]N(CC(=O)O)[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.54
ANPEP P15144 1/20 0.51
RNPEP Q9H4A4 1/20 0.51
DNPEP Q9ULA0 1/20 0.51
SLC1A3 P43003 1/20 0.49
SLC1A2 P43004 1/20 0.49
SLC1A1 P43005 1/20 0.49
ACE P12821 1/20 0.48
ALPI P09923 1/20 0.48
PKM P14618 1/20 0.48
PTGS1 P23219 1/20 0.48
XIAP P98170 1/20 0.48
SLC7A5 Q01650 1/20 0.48
MME P08473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL10956619 0.89 LTA4H (0.53) LTA4HANPEPRNPEPDNPEPSLC1A3
Leucine SCHEMBL5653346 0.87 LTA4H (0.56) LTA4HANPEPRNPEPDNPEPSLC1A3
Leucine SCHEMBL8740479 0.83 LTA4H (0.60) LTA4HANPEPRNPEPDNPEPSLC1A3
SCHEMBL10959619 0.82 MME (0.63) LTA4HACEMME
Leucine SCHEMBL10956565 0.82 LTA4H (0.54) LTA4HANPEPRNPEPDNPEPSLC1A3
Leucine SCHEMBL8019054 0.82 LTA4H (0.59) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL10945389 0.79 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Dl-Phenylalanine SCHEMBL31087886 0.79 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL2634732 0.79 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
D-Phenylalanine SCHEMBL10775923 0.79 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4513009-A GLYCINE, ALANINE AND SERINE DERIVATIVES SOCIETE CIVILE BIOPROJET (FR) 1985-04-23 US disclosed