Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2B | P67870 | 7/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954542 | 0.81 | KMT2A (0.50) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL10946120 | 0.81 | KMT2A (0.50) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL10951911 | 0.79 | KMT2A (0.45) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL10957000 | 0.79 | KMT2A (0.45) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL10950099 | 0.78 | CSNK2B (0.43) | CSNK2BCSNK2A1KMT2AMEN1CSNK2A2 | |
| SCHEMBL10378389 | 0.74 | ALDH1A1 (0.38) | CSNK2BCSNK2A1KMT2ACSNK2A2ABCG2 | |
| SCHEMBL1514634 | 0.69 | KMT2A (0.76) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL9458995 | 0.68 | KMT2A (0.48) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL23231528 | 0.66 | CSNK2B (0.50) | CSNK2BCSNK2A1KMT2AMEN1KDM4E | |
| SCHEMBL261280 | 0.65 | CSNK2B (1.00) | CSNK2BCSNK2A1KMT2AMEN1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |