Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2B | P67870 | 5/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10948857 | 0.78 | CSNK2B (0.48) | CSNK2BCSNK2A1CSNK2A2ABCG2MAPT | |
| SCHEMBL10954844 | 0.74 | MAPK1 (0.39) | MAPK1MAPTL3MBTL1ALDH1A1RAF1 | |
| SCHEMBL10949738 | 0.74 | MAPK1 (0.39) | MAPK1MAPTL3MBTL1ALDH1A1RAF1 | |
| SCHEMBL10376481 | 0.72 | ALOX15 (0.48) | MAPK1MAPTEGFRALDH1A1LMNA | |
| SCHEMBL6476126 | 0.68 | ALOX5 (0.47) | KMT2AALOX5 | |
| SCHEMBL10951911 | 0.67 | KMT2A (0.45) | MAPK1MAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL10954542 | 0.66 | KMT2A (0.50) | MAPTL3MBTL1ALDH1A1LMNAKMT2A | |
| SCHEMBL10946120 | 0.66 | KMT2A (0.50) | MAPTL3MBTL1ALDH1A1LMNAKMT2A | |
| SCHEMBL11490030 | 0.65 | ALDH1A1 (0.46) | CSNK2BCSNK2A1CSNK2A2ABCG2MAPK1 | |
| SCHEMBL30886455 | 0.62 | ALDH1A1 (0.67) | MAPK1MAPTL3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |