Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953004 | 0.79 | ALDH1A1 (0.47) | BRD4KMT2AMEN1CDC25BALDH1A1 | |
| SCHEMBL10949125 | 0.78 | ALDH1A1 (0.50) | BRD4KMT2AMEN1CDC25BALDH1A1 | |
| SCHEMBL10949178 | 0.72 | MAOB (0.44) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL10932260 | 0.71 | MAOB (0.50) | BRD4KMT2AMEN1ALDH1A1MAPK1 | |
| Anthraquinone SCHEMBL27283959 | 0.70 | MEN1 (0.75) | KMT2AMEN1CDC25BALDH1A1MAPK1 | |
| SCHEMBL23409702 | 0.68 | MEN1 (0.55) | KMT2AMEN1CDC25BALDH1A1MAPK1 | |
| SCHEMBL31691770 | 0.68 | MEN1 (0.55) | KMT2AMEN1CDC25BALDH1A1MAPK1 | |
| SCHEMBL1038974 | 0.67 | ADORA2A (0.57) | KMT2AMEN1CDC25BALDH1A1MAPK1 | |
| Anthraquinone SCHEMBL26662091 | 0.67 | MEN1 (0.92) | KMT2AMEN1CDC25BALDH1A1MAPK1 | |
| SCHEMBL11136509 | 0.67 | HSD17B10 (0.38) | BRD4KMT2AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |