Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951269 | 0.81 | PDE4B (0.42) | ALDH1A1MAPTSMN1; SMN2TDP1HIF1A | |
| SCHEMBL10954036 | 0.81 | PDE4B (0.42) | ALDH1A1MAPTSMN1; SMN2TDP1HIF1A | |
| SCHEMBL10954064 | 0.79 | MAPT (0.41) | MAOBALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL10952060 | 0.79 | MAPT (0.41) | MAOBALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL11564349 | 0.74 | HSD17B10 (0.48) | ALDH1A1SMN1; SMN2TDP1CYP1A2CYP2C9 | |
| SCHEMBL10949854 | 0.72 | BRD4 (0.46) | MAOBALDH1A1MAPTCASP3SMN1; SMN2 | |
| SCHEMBL18701282 | 0.72 | MAPT (0.39) | ALDH1A1MAPTSMN1; SMN2HTTCYP2C19 | |
| SCHEMBL20207728 | 0.72 | MAPT (0.43) | ALDH1A1MAPTSMN1; SMN2HTTCYP2C19 | |
| SCHEMBL10952676 | 0.71 | ALDH1A1 (0.43) | MAOBALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL10932260 | 0.71 | MAOB (0.50) | MAOBALDH1A1MAPTSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |