Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ATM | Q13315 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926212 | 0.95 | MEN1 (0.47) | MEN1KMT2AATMHRH1ALOX5 | |
| SCHEMBL10926835 | 0.95 | HRH1 (0.53) | MEN1KMT2AATMHRH1ALOX5 | |
| SCHEMBL10922803 | 0.95 | MEN1 (0.57) | MEN1KMT2AATMDRD3DRD2 | |
| SCHEMBL10923780 | 0.91 | MEN1 (0.55) | MEN1KMT2AATMHRH1DRD3 | |
| SCHEMBL10926867 | 0.90 | MEN1 (0.49) | MEN1KMT2AATMHRH1ALOX5 | |
| SCHEMBL10925373 | 0.88 | MEN1 (0.55) | MEN1KMT2AATMHRH1ALOX5 | |
| SCHEMBL10927224 | 0.83 | ACHE (0.46) | MEN1KMT2AATMHRH1DRD3 | |
| SCHEMBL10926532 | 0.83 | SMN1; SMN2 (0.55) | MEN1KMT2AATMDRD3DRD2 | |
| SCHEMBL10927393 | 0.80 | LMNA (0.43) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10928252 | 0.80 | TP53 (0.50) | ATMDRD3DRD2DRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |