Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926867 | 0.87 | MEN1 (0.49) | LMNA | |
| SCHEMBL10922803 | 0.84 | MEN1 (0.57) | LMNAALDH1A1 | |
| SCHEMBL10927399 | 0.83 | TSHR (0.39) | LMNASMN1; SMN2TSHRTHRB | |
| SCHEMBL10924892 | 0.82 | LMNA (0.51) | LMNASMN1; SMN2TSHRALDH1A1THRB | |
| SCHEMBL10926212 | 0.82 | MEN1 (0.47) | — | |
| SCHEMBL10927224 | 0.82 | ACHE (0.46) | LMNASMN1; SMN2 | |
| SCHEMBL10923780 | 0.82 | MEN1 (0.55) | LMNASMN1; SMN2 | |
| SCHEMBL10928252 | 0.80 | TP53 (0.50) | LMNASMN1; SMN2TSHRALDH1A1RAB9A | |
| SCHEMBL10950764 | 0.80 | MEN1 (0.55) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10930333 | 0.79 | ALDH1A1 (0.40) | LMNASMN1; SMN2ALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | claimed |
| EP-0189771-A3 | (ISOXAZOL-3-YL)ARYLMETHANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0189771-A2 | (Isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-08-06 | — | — | EP | disclosed |
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |