Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201035 | 0.78 | CYP2D6 (0.39) | L3MBTL1MEN1KMT2A | |
| SCHEMBL15564590 | 0.77 | CFTR (0.44) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3119634 | 0.75 | ADRB2 (0.40) | CYP2C19SLC6A4SLC6A3CYP19A1HSD17B10 | |
| SCHEMBL1338441 | 0.71 | CYP3A4 (0.43) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22383612 | 0.71 | CYP3A4 (0.39) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL242307 | 0.70 | SLC6A2 (0.42) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9129258 | 0.69 | CYP3A4 (0.44) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23539762 | 0.67 | SLC6A2 (0.39) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4758242 | 0.67 | SLC6A2 (0.39) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3106209 | 0.67 | SLC6A2 (0.39) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500535-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1985-02-19 | — | — | US | disclosed |
| US-4371696-A | ANTIINFLAMMATORY AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1983-02-01 | — | — | US | disclosed |