Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 7/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | BCKDK | O14874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955250 | 0.91 | TBXAS1 (0.55) | TBXAS1GPR35MCL1BCL2L1TAAR1 | |
| SCHEMBL11287291 | 0.81 | TBXAS1 (0.55) | TBXAS1GPR35TAAR1RXFP1PKM | |
| SCHEMBL10956131 | 0.81 | TAAR1 (0.36) | TBXAS1TAAR1 | |
| SCHEMBL10953013 | 0.79 | TBXAS1 (0.42) | TBXAS1TAAR1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL10952974 | 0.75 | TBXAS1 (0.60) | TBXAS1GPR35MCL1BCL2L1BCL2 | |
| SCHEMBL31207832 | 0.73 | TBXAS1 (0.58) | TBXAS1GPR35MCL1BCL2L1BCL2 | |
| SCHEMBL10855300 | 0.71 | TBXAS1 (0.54) | TBXAS1TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15619574 | 0.71 | MCL1 (0.71) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL10953675 | 0.70 | TBXAS1 (0.57) | TBXAS1GPR35PKMNPSR1NPC1 | |
| SCHEMBL10953653 | 0.70 | ROCK1 (0.45) | TBXAS1TAAR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4551468-A | INDOLE, BENZOFURANS, BENZOTHIOPHENES | PFIZER INC. (US) | 1985-11-05 | — | — | US | disclosed |
| EP-0050957-B1 | HETEROCYCLIC THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1984-08-22 | — | — | EP | disclosed |
| US-4410539-A | Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them | PFIZER INC. (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0050957-A1 | Heterocyclic thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-05-05 | — | — | EP | disclosed |