Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.60 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BCKDK | O14874 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10948748 | 0.88 | TBXAS1 (0.60) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL31207832 | 0.86 | TBXAS1 (0.58) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL10956255 | 0.84 | TBXAS1 (0.44) | TBXAS1GPR35MCL1BCL2L1NPSR1 | |
| SCHEMBL15619574 | 0.83 | MCL1 (0.71) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL10951715 | 0.78 | POLB (0.43) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL2895958 | 0.78 | GPR35 (0.58) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL2895162 | 0.78 | BCKDK (0.67) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL12153769 | 0.78 | MCL1 (0.71) | TBXAS1GPR35MCL1BCL2L1RXFP1 | |
| SCHEMBL10953675 | 0.76 | TBXAS1 (0.57) | TBXAS1GPR35PKMNPSR1NPC1 | |
| SCHEMBL10955250 | 0.76 | TBXAS1 (0.55) | TBXAS1GPR35MCL1BCL2L1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4551468-A | INDOLE, BENZOFURANS, BENZOTHIOPHENES | PFIZER INC. (US) | 1985-11-05 | — | — | US | disclosed |
| EP-0050957-B1 | HETEROCYCLIC THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1984-08-22 | — | — | EP | disclosed |
| US-4410539-A | Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them | PFIZER INC. (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0050957-A1 | Heterocyclic thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-05-05 | — | — | EP | disclosed |