Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9619840 | 0.78 | APP (0.36) | RAB9A | |
| SCHEMBL11318218 | 0.78 | APP (0.38) | RAB9A | |
| Hydrochloric Acid SCHEMBL9619839 | 0.77 | APP (0.35) | RAB9A | |
| SCHEMBL6293418 | 0.72 | APP (0.34) | — | |
| SCHEMBL4600856 | 0.72 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CRHR1MAPTBRD4 | |
| SCHEMBL3316223 | 0.72 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1ACHEKDM4EMAPT | |
| SCHEMBL14065132 | 0.72 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1CRHR1MAPTMEN1 | |
| SCHEMBL28338685 | 0.70 | TAAR1 (0.44) | ALDH1A1L3MBTL1CRHR1KDM4EMAPT | |
| SCHEMBL28154517 | 0.69 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACHECRHR1KDM4E | |
| SCHEMBL10837346 | 0.69 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1ACHEKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4557856-A | Electrically conductive composition for electro-responsive recording materials | MITA INDUSTRIAL CO., LTD. (JP) | 1985-12-10 | — | — | US | disclosed |
| US-4214031-A | LAYERS OF CATIONIC AND ANIONIC RESINS | MITA INDUSTRIAL COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |