Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953062 | 1.00 | LMNA (0.68) | LMNATSHRCHRM3MEN1KMT2A | |
| SCHEMBL28129212 | 0.81 | CHRM3 (0.70) | LMNATSHRCHRM3MEN1KMT2A | |
| SCHEMBL28129211 | 0.81 | CHRM3 (0.70) | LMNATSHRCHRM3MEN1KMT2A | |
| SCHEMBL7365405 | 0.80 | LMNA (0.68) | LMNATSHRMEN1KMT2AUSP2 | |
| SCHEMBL7365408 | 0.80 | LMNA (0.68) | LMNATSHRMEN1KMT2AUSP2 | |
| SCHEMBL5487379 | 0.80 | LMNA (0.72) | LMNACHRM3MEN1KMT2AUSP2 | |
| SCHEMBL5487375 | 0.80 | LMNA (0.72) | LMNACHRM3MEN1KMT2AUSP2 | |
| SCHEMBL11002647 | 0.78 | LMNA (0.70) | LMNATSHRMEN1KMT2AUSP2 | |
| SCHEMBL11002645 | 0.78 | LMNA (0.70) | LMNATSHRMEN1KMT2AUSP2 | |
| SCHEMBL10956251 | 0.78 | LMNA (0.59) | LMNATSHRCHRM3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089900-B1 | NEW N-((2-OXO-1-PYRROLIDINYL)ACETYL)PIPERAZINES, THE METHODS OF PRODUCING SUCH NEW COMPOUNDS AND THEIR SALTS AS WELL AS PHARMACEUTICAL PREPARATIONS FOR THERAPEUTIC USE CONTAINING THESE COMPOUNDS OR SALTS | PRODES S.A. (ES) | 1985-12-27 | — | — | EP | disclosed |
| EP-0089900-A1 | New N-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts | PRODES S.A. (ES) | 1983-09-28 | — | — | EP | disclosed |