Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.61 |
| ▸ | CDK2 | P24941 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159298 | 0.88 | MAPT (0.63) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL10960186 | 0.86 | ALDH1A1 (0.56) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL11008126 | 0.83 | CCNA2 (0.48) | MAPTNPC1RAB9AALDH1A1CCNA2 | |
| SCHEMBL10956678 | 0.81 | CCNA2 (0.44) | MAPTNPC1RAB9AALDH1A1CCNA2 | |
| SCHEMBL10957323 | 0.80 | CDK2 (0.63) | MAPTNPC1RAB9AALDH1A1CCNA2 | |
| SCHEMBL10954333 | 0.80 | CLK2 (0.52) | MAPTNPC1RAB9AALDH1A1CCNA2 | |
| SCHEMBL10956535 | 0.79 | CLK2 (0.48) | MAPTNPC1RAB9AALDH1A1CCNA2 | |
| SCHEMBL10955595 | 0.78 | MAPT (0.48) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL4400357 | 0.77 | RAB9A (0.86) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL5724705 | 0.76 | CCNA2 (0.78) | MAPTNPC1RAB9ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0008047-A1 | 5(6)-(2-Amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-02-20 | — | — | EP | disclosed |