Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10956535 | 0.97 | CLK2 (0.48) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL11008126 | 0.90 | CCNA2 (0.48) | CDK5HCAR3NPC1SMN1; SMN2MAPT | |
| SCHEMBL10958069 | 0.88 | MAPT (0.56) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10957090 | 0.87 | CLK2 (0.58) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10954761 | 0.85 | ALDH1A1 (0.55) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10956678 | 0.85 | CCNA2 (0.44) | NPC1SMN1; SMN2MAPTCCNA2CDK2 | |
| SCHEMBL10960186 | 0.84 | ALDH1A1 (0.56) | CDK5NPC1SMN1; SMN2MAPTCCNA2 | |
| SCHEMBL10957323 | 0.84 | CDK2 (0.63) | LIMK1HCAR3NPC1SMN1; SMN2MAPT | |
| SCHEMBL10954332 | 0.81 | MAPT (0.48) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10955467 | 0.81 | CLK2 (0.65) | CLK2GSK3AGSK3BCDK9LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |