Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10950741 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1ALOX5CES1MEN1 | |
| SCHEMBL10949738 | 0.70 | MAPK1 (0.39) | CES1MEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL10954844 | 0.70 | MAPK1 (0.39) | CES1MEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL10957000 | 0.63 | KMT2A (0.45) | PTGS2PTGS1ALOX5MEN1ALDH1A1 | |
| SCHEMBL9532243 | 0.61 | PTGS2 (0.75) | PTGS2PTGS1ALOX5ALDH1A1LMNA | |
| SCHEMBL5811709 | 0.60 | ALDH1A1 (0.59) | MEN1ALDH1A1MAPTMAPK1BLM | |
| SCHEMBL29906401 | 0.60 | ALDH1A1 (0.59) | MEN1ALDH1A1MAPTMAPK1BLM | |
| SCHEMBL5817279 | 0.60 | ALDH1A1 (0.44) | CES1MEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL10949125 | 0.58 | ALDH1A1 (0.50) | MEN1ALDH1A1MAPTMAPK1BLM | |
| SCHEMBL13668567 | 0.58 | ALDH1A1 (0.57) | CES1MEN1ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |