Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957016 | 0.88 | NPC1 (0.51) | MAPTMEN1KMT2AHCAR3RIPK1 | |
| SCHEMBL10954333 | 0.81 | CLK2 (0.52) | MAPTMEN1KMT2AHCAR3L3MBTL1 | |
| SCHEMBL10956535 | 0.78 | CLK2 (0.48) | MAPTMEN1KMT2AHCAR3RIPK1 | |
| SCHEMBL10956624 | 0.76 | KMT2A (0.48) | MAPTMEN1KMT2AHCAR3MAPK14 | |
| SCHEMBL28102683 | 0.73 | MEN1 (0.66) | MAPTMEN1KMT2AHCAR3GAA | |
| SCHEMBL12658567 | 0.73 | HCAR3 (0.53) | MAPTMEN1KMT2AHCAR3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11293453 | 0.72 | HCAR3 (0.52) | MAPTMEN1KMT2AHCAR3L3MBTL1 | |
| SCHEMBL10954328 | 0.71 | MAPT (0.44) | MAPTMEN1KMT2AHCAR3GAA | |
| SCHEMBL5568758 | 0.70 | NPC1 (0.56) | MAPTKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL15445145 | 0.70 | NPC1 (0.43) | MAPTMEN1KMT2AGAAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |