Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | CDK9 | P50750 | 1/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957090 | 0.87 | CLK2 (0.58) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10954333 | 0.81 | CLK2 (0.52) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10956535 | 0.78 | CLK2 (0.48) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10958069 | 0.77 | MAPT (0.56) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL11010419 | 0.74 | CCNA2 (0.55) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL10954761 | 0.74 | ALDH1A1 (0.55) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL18411106 | 0.71 | CDK5 (0.65) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL5570000 | 0.71 | NPC1 (0.48) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL4800949 | 0.70 | ALDH1A1 (0.49) | CLK2GSK3AGSK3BCDK9LIMK1 | |
| SCHEMBL11436301 | 0.70 | ADORA2A (0.45) | CCNA2CDK2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |