Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11003187 | 0.88 | APP (0.55) | APPLMNAHTTNPC1EPHX2 | |
| SCHEMBL14229047 | 0.81 | APP (0.50) | APPLMNAHTTNPC1L3MBTL1 | |
| SCHEMBL10877563 | 0.81 | LMNA (0.56) | LMNAHTTNPC1EPHX2L3MBTL1 | |
| SCHEMBL10948188 | 0.81 | LMNA (0.56) | LMNAHTTNPC1EPHX2GAA | |
| SCHEMBL27003568 | 0.80 | EPHX2 (0.46) | EPHX2GAAL3MBTL1KMT2ANPSR1 | |
| SCHEMBL10778354 | 0.80 | POLB (0.66) | POLBAPEX1TDP1LMNAHTT | |
| SCHEMBL6993505 | 0.79 | L3MBTL1 (0.58) | APPL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL1515840 | 0.78 | LMNA (0.54) | LMNAHTTNPC1EPHX2GAA | |
| SCHEMBL14200735 | 0.78 | APP (0.47) | APPLMNAHTTNPC1L3MBTL1 | |
| SCHEMBL26177290 | 0.78 | CYP51A1 (0.67) | LMNAHTTL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4529604-A | N,N-Di-(n-Propyl)dopamine derivatives | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-16 | — | — | US | disclosed |