Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200828 | 0.93 | HDAC3 (0.45) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14229047 | 0.85 | APP (0.50) | APPMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL14543451 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14200797 | 0.81 | TSPO (0.50) | MEN1KMT2A | |
| SCHEMBL14200898 | 0.80 | HDAC1 (0.40) | LMNANPC1HPGDRAB9ATP53 | |
| SCHEMBL14200831 | 0.79 | LDHA (0.43) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14200852 | 0.79 | RIPK1 (0.51) | ALDH1A1HTTNPSR1NPC1HPGD | |
| SCHEMBL14200786 | 0.79 | TSHR (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14200767 | 0.78 | LDHA (0.42) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL10956705 | 0.78 | POLB (0.56) | APPMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |