Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.50 |
| ▸ | IGF1R | P08069 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979777 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1HPGDSMN1; SMN2HIF1A | |
| SCHEMBL10957578 | 0.74 | ADORA3 (0.42) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL8321111 | 0.72 | CYP1A2 (0.65) | KDM4EALDH1A1SMN1; SMN2NTRK1NTRK2 | |
| SCHEMBL10957936 | 0.71 | CYP1A2 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL30743937 | 0.71 | NTRK1 (0.91) | KDM4EALDH1A1HPGDNTRK1NTRK2 | |
| SCHEMBL21295418 | 0.71 | NTRK1 (0.91) | KDM4EALDH1A1HPGDNTRK1NTRK2 | |
| SCHEMBL10956542 | 0.70 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10750340 | 0.69 | PDE3B (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL5126580 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1HPGDSMN1; SMN2HIF1A | |
| SCHEMBL3030044 | 0.69 | CYP1A2 (0.64) | ALDH1A1SMN1; SMN2NTRK1NTRK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0176333-A2 | Substituted quinazolinediones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-04-02 | — | — | EP | disclosed |