Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10960500 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL10710095 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL10964992 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL11037767 | 0.76 | XDH (0.56) | ALDH1A1HPGDMAPTMEN1GAA | |
| SCHEMBL10962527 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL7173914 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL27984516 | 0.75 | ALOX5 (0.43) | ALDH1A1HPGDHSD17B10MEN1GAA | |
| SCHEMBL12005105 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10TDP1MAPT | |
| SCHEMBL10334279 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL17029240 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HPGDALOX15HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088346-B1 | 2-AMINOMETHYL-PHENOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| EP-0088346-A2 | 2-Aminomethyl-phenol derivatives, process for their preparation, their use and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-14 | — | — | EP | disclosed |