Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280920 | 0.78 | PDE3B (1.00) | PDE2APDE3BPDE3AHTTFGFR1 | |
| SCHEMBL10963015 | 0.75 | PDE3B (0.66) | PDE2APDE3BPDE3AMAOB | |
| SCHEMBL10629606 | 0.74 | PDE3B (0.62) | PDE2APDE3BPDE3AHTTSMN1; SMN2 | |
| SCHEMBL517561 | 0.74 | MAOB (0.74) | MAOB | |
| SCHEMBL2531256 | 0.74 | HTT (0.78) | PDE2APDE3BPDE3AHTTFGFR1 | |
| SCHEMBL10960086 | 0.73 | PDE3B (0.62) | PDE3BPDE3AMAOBMGAMGAA | |
| SCHEMBL30402227 | 0.72 | HTT (0.88) | HTTFGFR1KDM4EALDH1A1RAB9A | |
| SCHEMBL3419279 | 0.72 | HTT (0.88) | HTTFGFR1KDM4EALDH1A1RAB9A | |
| SCHEMBL10960764 | 0.72 | MAOB (0.49) | PDE3BPDE3AMAOB | |
| SCHEMBL18731746 | 0.71 | HTT (0.79) | PDE2APDE3BPDE3AHTTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0149543-A1 | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-07-24 | — | — | EP | claimed |
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | claimed |
| EP-0149543-A1 | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | disclosed |