Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10964561 | 0.98 | KDM1A (0.46) | KDM1ACHEK1GAAKDM4EALDH1A1 | |
| SCHEMBL10727341 | 0.85 | CHEK1 (0.41) | CHEK1GAAKDM4EALDH1A1LMNA | |
| SCHEMBL4344657 | 0.83 | LTA4H (0.52) | GAAKDM4EALDH1A1LMNACYP11B1 | |
| SCHEMBL1461854 | 0.82 | MEN1 (0.47) | GAAKDM4EALDH1A1LMNACYP11B1 | |
| SCHEMBL10160337 | 0.82 | KDM4E (0.55) | GAAKDM4EALDH1A1CYP11B1HPGD | |
| SCHEMBL7449452 | 0.81 | LTA4H (0.50) | GAAKDM4EALDH1A1LMNACYP11B1 | |
| SCHEMBL13917342 | 0.81 | CYP2C9 (0.53) | CHEK1GAAKDM4EALDH1A1CYP11B1 | |
| SCHEMBL9021143 | 0.81 | KDM1A (0.58) | KDM1AGAAKDM4EALDH1A1CYP11B1 | |
| SCHEMBL10408880 | 0.79 | KDM4E (0.52) | GAAKDM4EALDH1A1CYP11B1HPGD | |
| SCHEMBL10726997 | 0.79 | FYN (0.58) | KDM1ACHEK1KDM4EALDH1A1CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146862-A2 | Pyridyl thiophenes | MERCK PATENT GmbH (DE) | 1985-07-03 | — | — | EP | disclosed |